1+ months

Associate Director, Protein Sciences

Kelly Services
La Jolla, CA 92037
**Kelly Science and Clinical** is the worlds most recognized brand in science and clinical staffing with more than 100 locations in North America, Europe, and the Pacific Rim. Our scientists contribute to the research and development of the next generation of small molecule drugs, biologics and cellular therapies.

**Overview and Responsibilities**

We are seeking a Principal Scientist / Associate Director to lead the protein engineering and expression team within the biologics discovery team at one of our clients, a nonprofit translational research institute dedicate to developing the next generation of medicines. This position will be responsible for directing a group of scientists to design, produce, and characterized protein candidates that have the potential to become next generation therapies. The team will work as part of a larger team of interdisciplinary scientists to profile molecules, select leads, and translate candidates into first in human clinical trials. Programs under the responsibility of this position will focus on antibody engineering, including bi, tri, and multi-specific antibodies, in the development of novel immuno-oncology agents. However, the role will also provide protein to support to a wide range of projects including infectious and neglected tropical diseases, metabolic disorders, autoimmunity, and other rare disease indications. This position is expected to bring with them the proficiencies listed below and can expect to receive world class training in translational medicine. Primary responsibilities will include resource management, keeping up to date on current literature, development and implementation of state-of-the-art processes, infrastructure/instrumentation management, development of reports, presentations to key stakeholders, database management, and management of personnel. Wet lab work may be within the scope of this position to train personnel in cloning, protein expression and purification, and biophysical characterization. Candidates with exceptional experience in antibody engineering who are looking to take the next steps in their career and join a high impact team are encouraged to apply. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within their team


+ A strong background in protein expression platforms including HEK, CHO, E. coli, is essential. Experience in yeast and insect is advantageous.

+ A strong background in protein purification is essential. The candidate should be proficient at FPLC, HPLC, gravity drip columns, and a wide range of affinity and capture technologies including SEC, IEX, mixed-mode, etc.

+ A strong background in molecular biology including DNA isolation and purification, construct design, and assembly-based cloning is essential.

+ A strong background in biophysical characterization of proteins is essential. Important competencies include, but are not limited to, RP, IEX, SEC chromatography, biacore & octet, and HR-MS of proteins.

+ Experience in upstream and downstream process development is important but not required.

+ Experience in medium and high throughput protein expression is highly advantageous for this role.

+ Experience in tech transfer of processes to CROs is useful.

+ Experience in wave bag expressions and fermentations is helpful.

+ Outstanding organization skills and experience in preparing scientific and technical documents including detailed data reports, protocols, CoTs is important.

+ Experience using graphing programs such as Prism, Excel, JMP, or Spotfire software is important.

+ Experience in retro, lenti, or AAV based viral vectors is important but not essential

+ Masters degree with 7+ years experience; PhD with 6+ years experience, post degree, in protein chemistry, chemical biology, biochemistry or relevant scientific discipline.

+ Previous experience managing a team of scientists

+ Industry experience is strongly preferred, but outstanding candidates without industry experience may also be considered.

+ Excellent ability to perform hands on experiments, attention to detail, research, design, and organize project designs and maintain detailed documentation.

+ Highly motivated, creative, and devoted to project goals.

+ Able to collaborate proficiently and communicate effectively with colleagues and management teams.

+ Able to contribute in a meaningful way to scientific discourse.

+ Details of established essential functions for this position will be addressed/discussed during the interview process.

**You should know:** Your safety matters! Vaccination against COVID-19 may be a requirement for this job in compliance with current client and governmental policies. A Kelly recruiter will confirm and share more details with you during the interview process.

**Why Kelly** **** **?**

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.

**About Kelly** ****

At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live (plus, did we mention we provide a ton of benefits ?). Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.

Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (
Posted: 2022-05-18 Expires: 2022-07-18

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Associate Director, Protein Sciences

Kelly Services
La Jolla, CA 92037

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