**Director of Translational Medicine**




Description



Start-up company poised to leverage the power of active microbial communities to address high unmet medical needs. Our approach lies at the intersection of microbiology, chemistry, and genomics and uniquely enables us to harness the power of the microbiome and define the potential of this new therapeutic modality.



Founded by two leading academics in the microbiome field.



**Description of the Role**



We are currently seeking a highly motivated scientific leader to ensure rapid and thoughtful progression of our discovery portfolio from lead identification through IND enabling pharmacology and toxicology studies. The candidate will be required to manage our germ-free mouse facility, guide and execute IND-enabling in vivo studies, such as pharmacology, safety, toxicology, pharmacodynamics, and participate in regulatory submissions. You will be responsible for generating early preclinical data that supports further clinic investigation of our complex rationally designed microbial consortiums and engineered microbes in a variety of disease indications. You will be also responsible for biomarker discovery. The perfect candidate will have a deep understanding of the animal sciences and be able to guide animal model development in the rapidly evolving and exciting field of microbiome research. Prior experience managing or working in a germ-free mouse facility would be ideal, but not necessary. We are looking for a candidate with specific translational research experience in oncology, metabolic and autoimmune indications. The candidate should be scientifically rigorous and experimentally curious. The role will require meticulous planning and organization to maximize the value of our germ-free gnotobiotic animal facility by seamlessly integrating discovery and pre-clinical development activities, while managing a team of gnotobiotic specialists. In this role, you will be responsible for designing innovative in vivo studies to help unravel the numerous threads that intimately connect our health to the composition of the microbiome. In addition to being a thought leader in the organization, you will be overseeing the budget, operations and research focus of the vivarium. You will be expected to be a flexible, adaptable, and intellectually rigorous team member and you will play a critical role in the design and development of microbiome therapeutics at the absolute forefront of the field.



**Core responsibilities and opportunities are:**



Manage our germ-free animal facility



Lead all translational sciences including animal model development, pharmacology, and toxicology, including any external translational CRO assessment and management



Design careful in vivo studies in germ-free mice to elucidate the link between the microbiome and human health



Provide expert advice to guide research strategy, indication selections and portfolio decisions



Work rigorously as an individual and passionately as part of a team



**Desired Skills:**



Provide strategic direction in the execution and data interpretation of IND-enabling non-clinical studies



Proven track record of advancing projects through IND enabling studies and into early clinical analysis



Successfully submitted an IND or equivalent to allow clinical investigation



A deep understanding of metabolic and auto-immune animal model development and translatability is required



Direct management experience and team leadership skills are necessary



Must have an ability to think strategically and communicate clearly to set and guide the translational sciences strategy



Excellent verbal and written communication to enable efficient regulatory filings and interactions



Experience with live-bacterial-product (LBP) regulatory requirements is desirable



Requirements



**Key Qualifications**



MD or PhD in a relevant discipline (immunology or pharmacology preferred)



10+ years of industry experience in an applied translational science group successfully transitioning several projects from research to the clinic



Experience mentoring individuals, managing a group and leading a cross-functional team is highly desired



Functional knowledge of key metabolic and immunological mouse models



Experience with germ-free animal models is desired






**Why Kelly** **** **?**



Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.


**About Kelly** ****



At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live. Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.


Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (https://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm)