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15 days old

Discovery Research Scientist (Receptor-Ligand Interaction)

Kelly Services
Beltsville, MD 20705
**Discovery Scientist** Receptor-Ligand Interactions


Direct Hire/Salaried


Beltsville, MD


**Job Description**


Kelly Science is supporting our biopharmaceutical client who is focused on the discovery and development of novel immunomedicines for the treatment of cancer and other immune-related diseases. We are seeking an experienced scientist with a strong background in biochemistry and molecular biology to join our Discovery Research team. A successful candidate will develop and utilize methodologies to identify and validate functional protein-protein (receptor-ligand) interactions for orphan targets identified by our functional screening platforms. The candidate will play a key role in defining the mechanism of action of novel immunomodulatory proteins and validating candidate therapeutic agents. The selected candidate will work in a highly dynamic, proactive, multidisciplinary environment with the goal of rapidly moving novel biological medicines toward the clinic.


**Responsibilities**


+ Independently design and perform novel assays to isolate and characterize ligand/receptor pairs and protein complexes with an understanding of the complexity of identifying interactions in the plasma membrane and extracellular space.

+ Develop biochemical techniques such as crosslinking-mediated pull-down, tyramide-mediated proximity-labeling, and BioID/Air-ID-mediated proximity-labeling to screen for novel protein interactions.

+ Develop and implement techniques to validate binding interactions, which may include OCTET, SPR, ELISA, and FRET-based analyses.

+ Coordinate with team members to validate the function of novel protein interactions.

+ Manage external collaborations with CROs and academic partners.

+ Coordinate and prioritize tasks across multiple projects.

+ Communicate scientific results and conclusions in written reports and oral presentations.


**Required education and experience**


+ PhD in Biochemistry, Molecular Biology, or related field.

+ Minimum 2+ years of experience in industry is preferred.


**Qualifications**


+ Extensive experience in biochemical and protein chemistry techniques (protein IP and crosslinking, proximity-labeling, gel electrophoretic and Western analyses, Octet or SPR)

+ Experience with collecting and interpreting mass spectrometry-based proteomics data.

+ Demonstrated ability to independently investigate, compare, and incorporate new techniques and equipment.

+ Outstanding project management, organizational and multi-tasking skills.

+ Strong interpersonal skills, written and oral communication skills, and ability to work in matrix team environment.

+ Strong publication record.


**Why Kelly** **** **?**


Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.


**About Kelly** ****


At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live (plus, did we mention we provide a ton of benefits ?). Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.


Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (https://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm)
Posted: 2021-04-21 Expires: 2021-05-22

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Discovery Research Scientist (Receptor-Ligand Interaction)

Kelly Services
Beltsville, MD 20705

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