1+ months

Downstream Process Development Scientist, Protein Purification -Redwood City, CA

Kelly Services
Redwood City, CA 94061
**Downstream Process Development Scientist, Redwood City, CA**

**Direct Hire**

****Must have protein purification experience and at least 10 years of industry experience****

Kelly Scientific would like to present a direct hire Process Development Scientist opportunity at a protein engineering company in Redwood City, CA.

We are seeking a highly experienced Process Development Scientist with specific expertise in protein purification and recover. This individual will also use his/her experience and critical thinking skills to contribute to building an expanding process development group that can meet the demands of the organization. Strong experience in developing purification processes ready for transfer to CDMOs and overseeing scale up and manufacturing of clinical grade drug substance is required.


The Process Development Scientist will be responsible for:

+ Development of purification processes for newly evolved enzymes expressed in a variety of microbial and mammalian hosts.

+ Troubleshoot and adapt analytical methods to quantify yield, activity, and purity at various stages of the manufacturing process

+ Characterization of the physicochemical properties of newly evolved enzymes such as pI, molecular size, pH and temperature stability to provide relevant information purification development

+ Development of unit operations at the bench -scale 10L such as, centrifugation, homogenization, precipitation, ultra-filtration, depth filtration and chromatography

+ Production of purified enzymes for animal studies, reference standards, and preliminary stability studies

+ Working within multidisciplinary project teams to design and execute process development campaigns, interpreting data, and working with other team members to integrate results into process designs and overall project plans

+ Troubleshoot and maintain analytical and process equipment. Identify and evaluate new technologies for downstream processing and analysis

+ Authoring and review of equipment and process SOPs.

**Job Requirements/Skills/Education:**

+ BS, MS or Ph.D. in Biophysics, Biochemistry, or Biological Science, **BS with 10+ years, MS with 6+ years or Ph.D. with 0-3 years industry experience in purifying and analyzing enzymes**

+ Strong technical background and direct hands-on experience with downstream processing unit operations such as preparative chromatography, centrifugation, homogenization, micro filtration, ultra-filtration, sterile filtration, etc.

+ Sound understanding of protein biochemistry and recombinant protein expression in microbial and mammalian hosts relevant to downstream purification.

+ Independently investigate complex analytical problems and provide robust solutions

+ Proficient at protein purification using affinity, size exclusion, ion exchange, and hydrophobic interaction chromatography using AKTA FPLC systems.

+ Experimental design and data analysis capabilities including Design of Experiments (DOE).

+ Understanding of engineering issues involved in scale up and possesses both practical and analytical skills to implement relevant scale down models.

+ Ability to prioritize responsibilities, multi-task and remain flexible with changing needs.

+ Must be motivated and able to work under tight deadlines.

+ Excellent interpersonal and communication (oral and written) skills, documentation, organization, good record keeping, writing reports and SOPs.

+ Able to work effectively in cross functional teams to solve manufacturing problems or implement improved procedures.

+ Mentor and supervise staff as well as work effectively with management teams.

+ Some travel to manufacturing sites will be required

**_For immediate consideration, apply today!_**

**Why Kelly** **** **?**

With Kelly, youll have access to some of the worlds highest regarded scientific organizationsproviding you with opportunities to work on todays most challenging, research-intensive, and relevant projects. Our connections can lead you to innovative scientific pursuits youll be proud to help advance. We work with 90 of the Fortune 100 companies and found opportunities for more than 10,000 scientific professionals last year.

You pursued a career in science to fuel your quest for knowledge and your desire to make the world a better place. Let Kelly fuel your careerconnect with us today.

**About Kelly** ****

At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live. Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.

Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. at
Posted: 2019-09-30 Expires: 2019-11-18

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Downstream Process Development Scientist, Protein Purification -Redwood City, CA

Kelly Services
Redwood City, CA 94061

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