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1+ months

Gene Expression Senior Scientist

Kelly Services
Thousand Oaks, CA 91358
Kelly Science & Clinical has a new direct hire opportunity for a Molecular Biology Gene Expression Senior Scientist in Thousand Oaks, CA. Base salary is up to $140K, based on educational background and relevant experience, and is both bonus and stock option eligible. Relocation assistance is available for highly qualified candidates!


The successful candidate will work with the cargo development team to both improve the behavior of standard gene expression elements and identify new ones to pair with diverse cargo genes. The position will require the applicant to develop library construction approaches, work closely with the screening team to develop novel assays for high-throughput characterization of libraries and variants using NGS and single-cell assay approaches, as well as manage research associates to execute on projects. A strong candidate will have experience with mammalian gene expression and hands-on experience with a variety of high-throughput molecular construction and screening or selection approaches.


Responsibilities


+ Responsible for the design and screening of AAV based expression libraries for cargo potency and safety modulation.

+ Development of selection and screening assays to measure impact of cargo modifications.

+ Execution of molecular biology for library construction and NGS characterization assays to meet pre-clinical research goals.

+ Collaborations within the pre-clinical research, engineering, and data sciences teams for assay development and data analysis.

+ Keeping up to date with novel tools for gene expression, library construction, and screening.

+ Present findings to interdisciplinary scientific teams to seek input on key studies and propose data-driven decisions.

+ Develop a small scientific team, coordinate their efforts, and see to their scientific and professional improvement along with your own.


Requirements


+ PhD in Life Sciences with ~5+ years of PostDoc/Industry experience

+ Strong technical experience with all DNA assembly methods, library design, and NGS sample preparation and related data analysis.

+ Experience with high-throughput DNA screens.

+ Demonstrated capability of generating data-driven hypotheses and developing properly controlled assays for hypothesis testing.

+ Ability to articulate challenges within DMS (deep mutational scanning)

+ Excellent oral and written communication skills.

+ Collaborative mindset and a willingness to work with and provide mentorship to junior RAs.

+ Experience with viral delivered gene therapy constructs.

+ Experience with cell culture-based screens.

+ Experience with single cell assay platforms, such as ddPCR, 10x or Mission bio

+ Experience with gene expression modulation.


If you, or someone you know, would like to be considered for this opportunity please apply online this week and a recruiter will reach out to discuss next steps and help move you forward in the process.


**Why Kelly** **** **?**


Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.


**About Kelly** ****


At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live (plus, did we mention we provide a ton of benefits ?). Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.


Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (https://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm)
Posted: 2021-05-14 Expires: 2021-06-21

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Gene Expression Senior Scientist

Kelly Services
Thousand Oaks, CA 91358

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