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22 days old

Research Associate

Kelly Services
San Diego, CA 92108
Kelly Services has been providing outstanding employment opportunities to the most talented individuals in the marketplace. We are proud to offer a long-term temporary opportunity to work as a **Research Associate** at a prestigious Fortune 500 company working in **San Diego.**





**Important information:** This position is recruited for by a remote Kelly office, not your local Kelly branch. To be considered for this position, you must use the Submit Resume button to submit your resumes. If you have questions about the position, you may contact the recruiter for this position ( Brooke.Schoen@kellyservices.com ) however your resume must be received via the Submit Resume button included within.





**Job Title: Research Associate**



**Pay: $29.20 per hour depending on experience**




**Description**



Our purpose as a company is to discover and develop therapies that will change the course of human health. We value our passion for patients, quest for innovation, spirit of independence and love of challenge. With a presence in more than 70 countries - and growing we look for talented people to grow our business, advance our science and contribute to our unique culture. The key therapeutic platforms currently under investigation leverage a broad range of biological activities that allow for the development of novel paradigm-changing therapeutics. Our discovery research teams are organized into four Thematic Centers of Excellence (TCoE), including Protein Homeostasis, Epigenetics, Immuno-oncology and Inflammation & Immunology. Within each these areas, discovery research, translational research, and early clinical development are integrated into a single team.




Summary/Scope:

The Protein Homeostasis TCoE is built on our legacy IMiD compounds. This class of drugs promotes the destruction of transcription factors Ikaros and Aiolos via the cereblon E3 ligase complex, thereby achieving therapeutic efficacy in a range of human diseases. The molecular mechanism group in the Protein Homeostasis TCoE is seeking a wet-lab scientist to assist the development of novel cereblon modulating agents that target cancer-specific prosurvival programs to treat various cancer types, as well to define the underlying mechanism of response and resistance. Better understanding of the MOA of these agents will help us pinpoint the right disease indications, select sensitive patient population and devise rational combination therapies to combat resistance. The successful candidate will have the opportunity to work closely with discovery project teams and scientists across the PH TCoE functional areas and to present his or her work at project team meetings and to the senior research leadership.


Responsibilities will include, but are not limited to, the following:

Optimize and perform next generation sequencing libraries to define MOA of candidate agents

Genetic manipulation in cancer cell lines using CRISPR-Cas9 technology

Generate stable cancer cell lines via retroviral or lentiviral transduction

Conduct flow cytometry-based assays

Conduct routine cell based assays to characterize drug candidates

Design research protocols in collaboration with the principal investigator

Plan and execute scientific experiments related to one or more programs independently

Convey data analysis and interpretation to supervisor and colleagues

Communicate with peers and supervisors and foster teamwork

Contribute to collaborative efforts

Strong commitment to quality and reproducibility

Demonstrate adaptability


Skills/Knowledge Required:

Extensive experience working with RNA and generating next generation sequencing libraries

Extensive wet-lab experience with molecular and cell biology including molecular cloning, western blot, immunoprecipitation, flow cytometry, realtime-qPCR, ELISA, lentivirus preparation and infection, etc.

Extensive experience with Cas9-CRISPR mediated gene editing and RNAi

Highly motivated and strong team player with a high degree of independence

Innovative and critical thinking

Excellent time management and organizational skills

Strong communication skills, both written and oral


Education:

Bachelors degree in a scientific discipline with at least 3 years work experience or Masters degree with at least 2 years work experience.





**We invite you to bookmark our Web site and encourage you to review it regularly for new opportunities worldwide:** www.kellyservices.com at http://www.kellyservices.com/ **.**



**_Kelly Services is a U.S.-based Fortune 500 company. With our global network of branch locations, we are uniquely positioned to provide our customers with international staffing support and our employees with diverse assignments around the world._**



**Kelly Services is an Equal Opportunity Employer**




**Why Kelly** **** **?**



Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.




**About Kelly** ****



At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/non-traditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live. Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.


Kelly is an equal opportunity employer committed to employing a diverse workforce and providing accommodations for people with disabilities in all parts of the hiring process as required under its Employment Accommodation Policy. Kelly will work with applicants to meet accommodation needs that are made known to Kelly in advance.
Posted: 2020-10-02 Expires: 2020-11-02

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Research Associate

Kelly Services
San Diego, CA 92108

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