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22 days old

Research Scientist

Kelly Services
San Diego, CA 92108
Kelly Services has been providing outstanding employment opportunities to the most talented individuals in the marketplace. We are proud to offer a long-term temporary opportunity to work as a **Research Scientist** at a prestigious Fortune 500 company working in **San Diego.**


**Important information:** This position is recruited for by a remote Kelly office, not your local Kelly branch. To be considered for this position, you must use the Submit Resume button to submit your resumes. If you have questions about the position, you may contact the recruiter for this position ( Brooke.Schoen@kellyservices.com ) however your resume must be received via the Submit Resume button included within.


**Job Title: Research Scientist**


**Pay: $44 per hour**


**Job description:**


The Oncogenesis Thematic Research Center (TRC) is one of the fundamental research and early development engines delivering therapeutics to cancer patients, integrating early discovery research through translational and early clinical development. Our modality focuses on numerous aspects of protein homeostasis including the ubiquitin-proteasome system, protein translation, and RNA processing and stability allowing the group to capitalize on the cutting edge science that underpins the action of the companys most advanced drugs. Pioneering research around these modalities creates a very dynamic, exciting and creative environment that exploits excellent science in biology, biochemistry, structural biology, computational biology and translational development.



The Discovery Biology group within the Oncogenesis (TRC) focuses on delivering novel cancer therapeutics by engaging E3 ubiquitin ligases for targeted protein degradation. We are seeking a highly motivated Scientist with strong background in tumor biology and understanding of the ubiquitin-proteasome system (UPS) to participate in the discovery of novel targeted protein degradation drugs for hematology oncology projects.


The successful candidate will work collaboratively in a multi-disciplinary environment to


1) explore disease biology enabling identification of novel drug targets


2) develop and implement robust cellular assays to support discovery of small molecules as clinical development candidates


3) design and execute research strategies that further our understanding of the mechanisms of novel compounds and targets


4) develop collaboration and interact with external partners relevant to the target discovery efforts.


Responsibilities include utilizing disease models to design target validation studies and relevant assays in support of SAR, mechanism of action, mechanisms of resistance, biomarker selection, and disease positioning. The successful candidate will work within discovery project teams and with scientists across different functional areas and be expected to present her or his work at project team meetings and to research leadership.



Responsibilities will include, but are not limited to:

Work independently to design, execute, analyze, interpret and troubleshoot scientific experiments in molecular and cell biology, cellular biochemistry and assay development.

Contribute to computational analyses that leverage internal, public and partner datasets and empower data-driven decisions for new target prioritization and validation.

Accurately maintain written reports and present results in an organized and timely manner to research leadership.

Communicate effectively with peers and supervisors, foster teamwork and contribute to collaborative efforts.

Strong commitment to quality and demonstrate adaptability.


Skills/Knowledge Required:

Extensive experience designing, implementing and analyzing compound effect using multiple platforms (multi-parameter flow cytometry, Incucyte, Western blot, ELISA/MSD, and functional assays such as cytotoxicity, cell cycle and apoptosis) in the context of drug discovery is required. Experience working on lymphoma and/or myeloma tumor biology is a plus.

Hands-on experience in mammalian cell culture using primary, single and/or co-culture cell models, including genetic manipulation techniques such as CRISPR RNP nucleofection and/or lentiviral transduction.

Experience of computational biology research on a wide variety of molecular profiling platforms, including mRNA profiling, mutational profiling, DNA copy number quantification, epigenetic profiling and proteomics is desired.

Flexibility and interest in learning new techniques and skills in accordance with the research program needs.

Proficiency in scientific and data analysis programs including FlowJo, Microsoft Excel, PowerPoint, GraphPad Prism is required.

Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.



PREREQUISITES

Ph.D. level in cell biology, immunology, molecular biology or equivalent field with 0-3 years of experience, or M.S. degree with a minimum of 4-6 years of experience or BSc with a minimum of 6-8 years of experience in biopharmaceutical industry developing and optimizing cell-based assays.


The position level will be dependent on experience.


**We invite you to bookmark our Web site and encourage you to review it regularly for new opportunities worldwide:** www.kellyservices.com **.**


**_Kelly Services is a U.S.-based Fortune 500 company. With our global network of branch locations, we are uniquely positioned to provide our customers with international staffing support and our employees with diverse assignments around the world._**


**Kelly Services is an Equal Opportunity Employer**


**Why Kelly** **** **?**


Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.


**About Kelly** ****


At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live. Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.


Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (https://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm)
Posted: 2021-02-05 Expires: 2021-03-08

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Research Scientist

Kelly Services
San Diego, CA 92108

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