7 days old

Scientist/Senior Scientist, Protein Sciences

Kelly Services
South San Francisco, CA 94080
**Kelly Science and Clinical** is the worlds most recognized brand in science and clinical staffing with more than 100 locations in North America, Europe, and the Pacific Rim. Our scientists contribute to the research and development of the next generation of small molecule drugs, biologics and cellular therapies.


We are seeking a Scientist/Senior Scientist, Protein Sciences for one of our clients, a clinical stage biotechnology company in South San Francisco. The incumbent will have the opportunity to contribute to advancing their therapeutic platform in a fast-moving and dynamic R&D environment, and to help make a difference in the lives of cancer patients.


+ Collaborate with discovery, protein engineering and pharmacology to provide therapeutic protein candidates of appropriate quality for use in in vitro and in vivo studies.

+ Participate with protein engineering group in the design of discovery pipeline molecules.

+ Implement innovative mammalian cell culture strategies to improve production of Probodies, bispecific antibodies and cytokine molecules.

+ Develop parallel purification strategies for various bispecific formats, Probodies and cytokines.

+ Solve protein purification problems based on scientific principles, current technologies, and personal experience.

+ Implement strategies to generate CHO stable pools for lead panels of Probodies, ProTCBs and Procytokines.

+ Work with CROs to generate RCBs for all lead molecules in discovery pipeline.

+ Participate in cross-functional discovery support teams, and effectively communicate information to appropriate groups and protein sciences staff.

+ Develop analytical methods used for protein characterization (HPLC, RP-HPLC, HIC, CE-SDS, iCIEF, etc.) that are aligned with approaches used in later stages of development to assess product quality and potency.

+ Organize data and communicate results in internal and external scientific meetings.


+ PhD in Biochemistry or Protein Chemistry or related discipline with 4+ years of experience in the biotechnology or biopharma industry

+ Expertise in mammalian cell culture is required.

+ Expertise in protein/antibody production by transient transfection and stable cell generation is required.

+ Experience in molecular cloning, antibody sequencing, PCR and CRISPR technology is required.

+ Experience in the production and purification of antibodies and bispecific molecules in various formats is required

+ Expertise in operating the AKTA systems, Tecan or Janus liquid handler system is required.

+ Expertise in antibody modeling and sequence analysis for liabilities is required.

+ Should be well versed in therapeutic antibody protein characterization assays including affinity measurements by SPR

+ Familiarity with monoclonal antibody generation process is desired

+ Expertise in manufacturability assessment of therapeutic biologics molecules is required.

+ Hands on experience in operating the HPLC, Bioanalyzer, CE-SDS and iCIEF instruments is desired.

+ Experience in managing the protein purification workflow is required


**You should know:** Your safety matters! Vaccination against COVID-19 may be a requirement for this job in compliance with current client and governmental policies. A Kelly recruiter will confirm and share more details with you during the interview process.

**Why Kelly** **** **?**

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.

**About Kelly** ****

At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live (plus, did we mention we provide a ton of benefits ?). Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.

Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (
Posted: 2022-01-14 Expires: 2022-02-14

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Scientist/Senior Scientist, Protein Sciences

Kelly Services
South San Francisco, CA 94080

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