15 days old

Senior Scientist, Purification, Los Angeles, CA

Kelly Services
El Segundo, CA 90245
**Senior Scientist, Purification, Los Angeles, CA**

Kelly Science is seeking a Senior Scientist for an exciting new opportunity in the development of downstream operations of viral vaccine vectors and engineered NK cells. As an expert in purification for viral vectors and biologicals, you will lead the development of procedures for product capture and polishing, which include steps used to clear process- and product-related impurities in the production of biologic drug substance under cGMPs. You may also lead formulation development efforts. This position also offers a potential opportunity to later work with antibodies, Fc-fusion proteins, and other recombinant proteins.

_Apply today for immediate consideration and to learn more about this opportunity!_

**Type:** Direct-Hire

**Shift:** 1st, M-F

**Salary:** $90K and up DOE

**Responsibilities** :

+ The individual will develop and design efficient, robust purification processes that can be scaled to commercial production.

+ As the subject matter expert, the individual will play a lead role in tech transfer of developed processes to manufacturing and provide technical advice for troubleshooting manufacturing issues and aid in corrective and preventive actions.

+ Develop formulations, including lyophilized forms. He or she will also develop processes for manufacture of drugs in both parenteral and other dosage forms.

+ Use quality by design (QbD) techniques including use of DoE strategy for process development.

+ Identify trends in manufacturing and initiate continuous process improvement activities for increasing robustness and process yields.

+ Draft and review technical protocols, reports, and manufacturing deviation investigations. Present activities and results intra- and interdepartmentally, and to management.

+ Learn, maintain and advance expertise in areas relevant to companys products and strategic goals

+ Draft and edit documents for regulatory submissions as needed.

+ Leads and/or manages teams as needed. Assists in budget creation and identifying resource requirements.

+ Maintain laboratory preparedness including responsibilities for the PM, calibration, and operations of laboratory equipment.

+ Support manufacturing process changes, process validation, troubleshooting and investigation evaluations, change control, and regulatory submissions.


+ Ph.D. degree in biochemistry/chemistry/biochemical engineering with 7+ years or M.S. with 10 years, or B.S. with 12+ years of industrial experience with expertise in developing purification processes for viral vectors and biologicals.

+ Have in-depth knowledge of macromolecular biochemistry, and experience with statistical design of experiments (DOE) used in process and formulation development. Understand the factors affecting product quality

+ Experience with developing formulations for parenteral and solid dosage forms is preferred.

+ Strong experience in Chromatography IEX, Affinity, SEC, HPLC.

+ Working knowledge of Process analytical technologies like immunoassays, ELISA, gels, PCR, DSC, PSD, etc.

+ Experience with TFF, centrifugation and depth filtration.

+ Experience or strong understanding of Mammalian cell culture for gene therapy applications

Questions? Email

Schedule Time to Connect:

**Why Kelly** **** **?**

Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.

**About Kelly** ****

At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live. Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.

Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (
Posted: 2021-01-11 Expires: 2021-02-25

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Senior Scientist, Purification, Los Angeles, CA

Kelly Services
El Segundo, CA 90245

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