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1+ months

Sr. Research Associate-Primary cell culture/molecular biology

Kelly Services
South San Francisco, CA 94080
**Kelly Services is seeking a (Senior) Research Associate for a Permanent position in South San Francisco, CA.**


Our client is a next-generation biopharmaceutical start-up using human genomics to accelerate development of life-saving treatments for neurodegenerative diseases. Their platform uses patient tissue profiling, human genetics, and machine learning to identify new therapeutic gene targets, predict effective drugs, and stratify patient subpopulations for increased clinical success. Their approach offers a breakthrough opportunity to identify drugs that dramatically improve patient outcomes and fundamentally lower the cost curve of pharmaceutical development.


The newly formed Target Identification and Exploratory Biology team is seeking a creative and driven (Senior) Research Associate. In this position, you will be investigating the biology of neurodegenerative disorders, such as Parkinsons disease, Frontotemporal dementia and Amyotrophic lateral sclerosis. You will implement functional genomics technologies and phenotypic assays to explore gene function in disease relevant brain cell models. You will make important contributions to their mission by identifying and validating novel genetic targets to fill the company's therapeutic pipeline.



**Responsibilities**


Develop and execute cell based phenotypic assays based on high content imaging, genomics and proteomics approaches.

Validate targets using RNAi and CRISPR technology and pharmacological tools.

Maintain cell cultures, with a focus on human iPSC (neuron, astrocyte, microglia) and fibroblast models derived from patients, as well as primary brain derived cells.

Write detailed research project plans and SOPs.

Analyze data using relevant statistical methods.

Present results in team and company meetings.


**Job Requirements**


A BS + 5 years or MS + 3 years degree, preferably in neuroscience or cell-molecular biology, or a related scientific discipline is required.

Expertise in mammalian (primary) cell culture is required.

Experience with cell-based assay development and molecular biology techniques (e.g., RNA isolation, qPCR, and Western blots) is required.

Experience with data analysis using GraphPad Prism, SPSS, SAS, and Excel, and a general knowledge of statistical analysis is required.

Good communication skills and ability to collaborate in cross-functional group settings is required.


**Skill Preferred**


iPSC maintenance and differentiation skills is a plus.

Expertise in neurodegenerative or psychiatric disease biology and human genetics is a plus.

Experience with immunocytochemistry, light and fluorescence microscopy is preferred; prior experience with image analysis is a plus

Documentation of experiments using electronic lab notebooks is a plus.

Expertise in genomic technologies (RNAi, CRISPR) and drug testing approaches is a plus.

Help our client revolutionize the way drugs are discovered & developed:

The startup nature provides multiple growth opportunities into other areas of the company. As one of the early employees, your work will have a direct impact on the foundation of a groundbreaking new drug development model. In addition to competitive compensation and benefits, they offer perks like unlimited vacation/sick days, on-site gym access, and free lunch.


**APPLY NOW!**


**For immediate consideration, please send your resume in a WORD document to gaut985@kellyservices.com**


**You should know:** Your safety matters! Vaccination against COVID-19 may be a requirement for this job in compliance with current client and governmental policies. A Kelly recruiter will confirm and share more details with you during the interview process.


**Why Kelly** **** **?**


Kelly Science & Clinical is your connection to premier scientific and clinical companies looking to hire talented people just like you. Every day, we match science professionals with dream jobs that fit their skills and interestsits the way we think job searching should be. Nearly 100 percent of our science recruiters have a professional background/education in science, so we know a thing or two about the science market and how to get you noticed.


**About Kelly** ****


At Kelly, were always thinking about whats next and advising job seekers on new ways of working to reach their full potential. In fact, were a leading advocate for temporary/nontraditional workstyles, because we believe they allow flexibility and tremendous growth opportunities that enable a better way to work and live (plus, did we mention we provide a ton of benefits ?). Connecting great people with great companies is what we do best, and our employment opportunities span a wide variety of workstyles, skill levels, and industries around the world.


Kelly is an equal opportunity employer committed to employing a diverse workforce, including, but not limited to, minorities, females, individuals with disabilities, protected veterans, sexual orientation, gender identity. Equal Employment Opportunity is The Law. (https://www.dol.gov/ofccp/regs/compliance/posters/ofccpost.htm)
Posted: 2022-03-23 Expires: 2022-05-23

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Sr. Research Associate-Primary cell culture/molecular biology

Kelly Services
South San Francisco, CA 94080

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